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Oligomeric proanthocyanidins (OPC) were discovered by Dr. Jacques Masquelier as early as 1948. Since then, science has been working with the active substance and has proven and researched numerous positive effects in OPC studies. OPC has an antioxidant effect, reduces the risk of arterial calcification, supports blood pressure control, reduces edema, promotes wound healing, increases the elasticity of the skin, has anti-inflammatory, anti-mycotic, antibacterial and helps in the cure of various other diseases. [1] Robert Franz is probably one of the most important proponents of OPC and someone who has given the active ingredient increased attention. “Crucify me, but give all OPC” is a statement by Robert Franz. He has already published numerous videos and texts on this subject and made them accessible to the people. Experience supports, in addition to studies, the positive effects of OPC.

What is OPC?

OPC is a secondary plant substance. The substance is mainly present in tree barks, in the shell and in the skins of fruit and in shrubs and trees. A particularly high amount is present in grape seeds. In most cases, the oligomers proanthocyanidins are therefore used from grape seeds. The natural plant substance has a very wide range of effects and can be used in many ways without any side effects.

Robert Franz is an absolute advocate of natural remedies. It certifies that the active substance has a healing effect on the body and thus to have health. According to Robert Franz, a vital and healthy lifestyle is possible without resorting to products from the pharmaceutical industry. He trusts in the power of nature. Robert Franz already knows many as OPC-Franz, as he sees the grape seed extract as a natural way to prevent diseases and maintain a healthy lifestyle. Reports with OPC experiences are almost always positive. Buying OPC is therefore an investment in one’s own health.

gdp infografic OPC

How do oligomeric proanthocyanidins work?

Oligomeric proanthocyanidins act in different ways. The polyphenols contained in the OPC grape seed extract, especially proanthocyanidin, have numerous positive effects on health. The active substance fights the free radicals in the body. Proanthocyanidin is an extremely effective antioxidant. Free radicals are produced by stress, sunlight and pollutants, among other things. These free radicals cause damage. Oligomeric proanthocyanidins thus help to treat numerous health problems caused by the free radicals by combating these free radicals. OPC capsules with OPC grape seed extract can neutralize inflammation in the body due to their antioxidant effect and significantly increase the effectiveness of vitamin C. Protection against viruses, bacteria and chronic diseases can be increased. The arteries are protected from calcification. Flavonoids contained in grapes are said to lower cholesterol in the body, especially bad cholesterol, the LDL. The active substance causes a relaxation of the blood vessels and arteries. Furthermore, the blood can be diluted by the active ingredient. The result is a reduction in blood pressure.

The elasticity of the skin is increased by strengthening the connective tissue. Polyphenols are binders of collagen fibers, which, among other things, strengthens the arteries, connective tissue and joints. In addition, we improved the moisture barrier of the skin layer, through the alpha-hydroxy acid that is contained in the active ingredient. OPC capsules are very helpful for infections, dermatitis, cut wounds and excessive sunlight. This is due to the resveratrol contained in OPC grape seed extract. This active ingredient has antifungal, antibacterial and anti-inflammatory properties. Numerous experiences prove the positive effects on the body and thus on health. Buying OPC can contribute to a higher well-being and improved health, provided quality is taken into account. OPC should be high-dose and is also available as OPC Bio on the market.

Which product is the best?

Of course, it is important to pay attention to the quality of the product and the ingredients if you want to buy OPC. The strongest product currently available on the market is Sanasis OPC forte plus vitamin C from Acerola. The OPC is high-dose and contains the highest permitted amount of the active substance in Switzerland. The effectiveness is increased by gastro-resistant capsules. 150 mg of pure OPC is included per capsule. Fillers and sprinklers are not included in this product, so there are no magnesium stearates in these OPC capsules.

The production of the capsules without these aids is more complex and associated with a lot of manual work. Another excellent and innovative product is the liposomal OPC. The OPC is also high-dose with this product. The formulation in this product ensures an increased absorbability of the active ingredient. Phosphatidylcholine is formed by most human cells. This phospholipid is derived from European sunflowers and in itself forms an effective raw material, the basis for lecithin. The phospholipid complex forms small spheres during production by a special processing. These enclose the active substance so that it is not recognized by the digestive system and can reach its target unhindered. It enters the bloodstream and thus to the various cells. The active substance is therefore not or almost not absorbed by the digestive system. Thanks to this new technology, the active ingredients enter the bloodstream in significantly higher amounts.

If you want to buy OPC, you should pay attention to the ingredients and a high-quality grape seed extract. [2] The active ingredient significantly supports the effect of vitamin, a simultaneous intake, in particular of vitamin C and also vice versa, a strengthening effect is present, vitamin C supports the action of oligomeric proanthocyanidins. Simultaneous use is recommended, unless the active ingredients are already combined. Buying OPC means making a significant contribution to good health. OPC is the most effective high dose and therefore attention should be paid to the amount of active substance contained. OPC Bio is not mandatory or better, important are the ingredients and the amount of the active ingredient.


What complaints does OPC help against?

Lowering blood pressure

By taking it, blood circulation can be promoted. The OPC effect ensures that the vessels become more elastic and further. Tissue damage and damage to arteries are reduced. Blood circulation is improved and reduces inflammation in the body. The resistance of the blood vessels can double within twenty-four hours of ingestion, as the active substance attaches itself to the proteins elastin and collagen. This OPC effect is achieved with taking one to two capsules per day, depending on body weight and amount. When taking OPC powder, the dosage of one to three milligrams per kilogram of body weight also applies.

Protection against heart disease and stroke

In addition to lowering blood pressure, oligomeric proanthocyanidins reduce oxidized LDL. The LDL contributes to the development of atherosclerosis and damage to blood vessels. Free radicals also damage blood vessels. These are combated by OPC. The storage of cholesterol in the arteries is prevented. These deposits can lead to blockages of blood vessels and, depending on placement, lead to a heart attack, thrombosis or stroke. The dosage for prevention against heart disease and stroke is one to two capsules daily, depending on the body weight and proportion of the active ingredient contained. [3]

Lowering cholesterol levels

Studies have shown a reduction in cholesterol levels. In particular, the value of bad cholesterol could be reduced. The bad cholesterol is called LDL, the good cholesterol is called HDL. Numerous OPC experiences describe the positive effects in the blood count. The OPC dosage is to lower cholesterol levels at one to two capsules daily, depending on body weight and the amount of active ingredient contained. As with capsules, taking OPC powder is considered to be one to three milligrams per kilogram of body weight.

Improving blood circulation

Because the blood vessels are repaired and kept elastic by oligomeric proanthocyanidins, blood circulation improves. Better blood circulation also benefits the brain and allows for higher concentration. The metabolism of the brain is optimized. Parkinson’s, Alzheimer’s and dementia can be reduced or prevented. This OPC effect can be achieved at a dosage of one to two capsules daily, depending on body weight and contained amount of oligomers proanthocyanidins.

Effect on the skin

The active substance binds to the components of the vascular walls, the elastin and the collagen. The tissue and skin remain strong, the skin becomes supple and resistant again. This applies, of course, equally to the hair. In addition, the aging process is slowed down. This OPC effect can be achieved by taking one to two capsules per day, depending on body weight and amount of active ingredient.

Effect in the event of allergies

Allergies are reactions of the body to stimuli. Symptoms can be very different. In the case of an allergic reaction, the body releases histamines, which lead to the symptoms. In most cases, conventional medicine prescribes antihistamines. Oligomeric proanthocyanidins can affect histamine levels and thus contribute to an improvement in an allergic reaction. However, it is necessary to take it for a longer period of time. The OPC dosage should be in the case of allergies in one to two capsules daily, depending on the amount of active ingredient and body weight contained. OPC high dose shows the best effect. In case of allergies, it may be useful to use an OPC organic product.

Improved wound healing

The active substance alpha-hydrosyic acid contained in oligomeric proanthocyanidins contributes to an improved moisture barrier of the skin cells. Wounds heal much faster and sometimes scars become smaller. It is recommended to apply an additional external application of a cream containing oligomeric proanthocyanidins.

Healthy eyes

Taking OPC can significantly reduce eye strain and combat cataracts and macular degeneration. [4] Macular degeneration is an eye disease in which the cells of the retina die. In the central field of view, vision is impaired. Even at night, vision can be improved. The OPC dosage to support eye health is one to two capsules daily, depending on body weight and the amount of active ingredient contained.

Effect in cancer

Oligomeric proanthocyanidins can inhibit tumor growth and prevent or reduce the development of various cancers. As an accompanying therapy for chemotherapy, the active substance has also shown positive effects. This reduces side effects and sometimes kills the cancer cells, while healthy cells are not damaged. OPC experience show numerous positive effects of OPC. The dosage is one to two capsules per day depending on body weight and the amount of active ingredient contained.


OPC capsules ensure stable blood sugar levels and thus help with diabetes. [5] Diabetics very often have a relatively thick blood. Existing sugar swells poorly. The active ingredient thinners the blood and also blood sugar peaks can be broken down more quickly. The metabolism is improved, at the same time a strengthening of the blood vessels takes place. Dosage depends on body weight and the amount of active ingredient contained. It should be one to two capsules per day.

Reduction of platelet aggregation

Platelets cause the closure of injured blood vessels. However, they can also lead to thrombosis, i.e. the closure of vessels. The blood-thinning effect of OPC prevents the platelets from sticking together and thus prevents thrombosis. The OPC dosage is one to two capsules per day, depending on the amount of active ingredient and body weight of the individual.

How is OPC taken and at what dose?

In general, an intake of one to three milligrams per kilogram of body weight is recommended. Depending on the preparation and the amount of active ingredient contained, these are usually one to two capsules daily. The dose should be taken approximately half an hour to a full hour before the meal. People who react with stomach problems due to the bitter substances can also take the active ingredient with a meal or just before a meal. However, the OPC effect is neutralized by milk protein. Dairy products such as yoghurt, milk or cheese should be dispensed with both before and after consumption. If you take two OPC capsules per day, you should spread them into two receipts, i.e. one capsule in the morning and one capsule at noon. OPC powder is taken in the same dosage.

Conclusion: Why is OPC so healthy?

Numerous studies have already demonstrated the positive effects of OPC, while other studies are still being conducted. Oligomeric proanthocyanidins have extremely many positive health effects and are sometimes referred to as elixir of life. [6] There is virtually no area in which OPC studies have so far failed to show any positive effects. The main points that the active ingredient can have:

  • the strongest antioxidant effect
  • Tissue is regenerated
  • Wrinkles can be prevented
  • Protection against inflammation
  • Protection against allergies
  • Protection of the skin
  • Improving eye performance
  • Lowering cholesterol levels
  • Lowering blood pressure
  • Blood thinning
  • Help with diabetes
  • Support for cancer
  • Preventing platelet aggregation
  • improved blood flow

Hardly any other active ingredient has had so many positive effects. OPC is available in different dosage forms, in addition to capsules, OPC powder can also be used. Decisive for the effect is the amount of the active ingredient contained and of course the other ingredients. The products should not contain magnesium stearates and, of course, no harmful ingredients. The dosage is almost always the same, one to three milligrams of oligomeric proanthocyanidins per kilogram of body weight. This recommendation should not be significantly exceeded or exceeded as this may affect the effect. It is not based on the principle of ‘more, helps more’. OPC should be taken regularly so that the body can get used to the active ingredient and the positive effects are felt.

Source directory:

  1. https://www.verbraucherzentrale.de/wissen/lebensmittel/nahrungsergaenzungsmittel/fuer-immer-jung-mit-resveratrol-oder-opc-13389
  2. https://www.ncbi.nlm.nih.gov/pubmed/31275511
  3. https://utopia.de/ratgeber/opc-traubenkernextrakt-wirkungen-und-nebenwirkungen/
  4. https://www.ncbi.nlm.nih.gov/pubmed/31269652
  5. https://www.ncbi.nlm.nih.gov/pubmed/31151630
  6. https://www.atm.de/blog/redaktionelles/opc-wunderwaffe-radikalfaenger-auch-fuer-hunde
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