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Characterizations such as “organic solvent” and “sulfur-containing liquid” do not immediately make one think of a universal roofing agent of alternative medicine. But this is precisely what lies behind the technical name dimethylis sulfoxidum or dimethyl sulfoxide (DMSOfor short), which specifies the composition of this natural active ingredient. The thin-liquid substance has it in itself – as a health-promoting immunostimulant, wound remedy and metabolic accelerator. In addition, as a transport medium, it increases the efficiency and speed of many active ingredients in the fight against pain and disease.

What is DMSO?

At first glance inconspicuous, conspicuous at most by a vaporation that not everyone finds pleasant: dimethyl sulfoxide, a colourless, somewhat oily liquid, reminds us of garlic or wild garlic, a smell that takes a while to neutralize. It crystallizes at a temperature of 18 degrees, but liquefies again when heated. Also known as methyl sulfoxide, methylsulfinylmethane, sulfinyldimethane and dimethylis sulfoxidum is an organic sulfur compound. It is formed in the sea, is released into the atmosphere on the way of evaporation and reaches back and the earth with the rainwater.

It was discovered in 1866 by the Russian chemist Dr. Alexander Mikhailovich Zaitsev (1841 – 1910). The scientist noticed the versatility of the thin-liquid substance as a carrier and solvent for a wide variety of chemicals: methylsulfinylmethane absorbs both water-soluble substances (e.g. salts) and fat-soluble (e.g. oils) equally well.

Originally, the sulfur compound was extracted from the wood component lignin. It wasn’t until the early 1960s, nearly 100 years later, that an American transplant physician had dmSO experience that suggested that the cells of organs taken in mixtures with this substance appeared to stabilize and prolong the usability of the grafts. From that point on, DMSO and its effect on the human organism became increasingly in the interest of research. Industrial production processes have been developed which can meet the increasing demand for the substance and guarantee the high degree of purity required for use in the pharmaceutical industry.

Pharmaceutically certified dimethyl sulfoxide with a purity of 99.9 percent has been included in the European Pharmacopoeia with the certificate “Ph. Eur.” as a medical active substance. To buy DMSO, you don’t need a prescription. For an overview of the application of DMSO and experiences with it, it is recommended to use “The DMSO Manual” by Dr. rer. Nat. Hartmut P.A. Fischer.

gdp infografic DMSO

How does DMSO work?

Both conventional medicine and naturopathy describe numerous applications for the organic sulphur compound DMSO. Its effect has three aspects:

  • Dimethyl sulfoxide is an immunostimulating and regulating agent.
  • It can enhance and accelerate the action of other drugs or therapeutic procedures.
  • It provides valuable services in the extraction of active ingredients from medicinal plants and other natural substances.


All these options are explained by the above-described property as carrier and / or solvent for both water-soluble (hydrophilic) and fat-soluble (lipophilic) substances. DMSO’s numerous options for effect and application have been and are being researched and described thousands of times in medical studies. Among the most important therapeutic effects, as Dr. Fischer lists in his manual, are:

  • Restoration of injured tissue (accelerated wound healing)
  • softened scarring, smoothing of older scars
  • Protection and regeneration of cells and improvement of their oxygen saturation
  • faster transport processes in the body (including oxygen supply, disposal of radicals)
  • Healing inflammation, elimination of painful deposits
  • itching,reticing, antibacterial and antifungal (also helps against fungal infestation)
  • Normalization and consolidation of the functions of the vegetative nervous system, which regulates body processes such as blood pressure and respiratory rate
  • Relieving pain through short-term blockage of pain-causing nerves
  • Dissolution of muscle tension
  • Dilating blood vessels, improving blood circulation


Sulfinyldimethane supports and facilitates transport and exchange in biological supply systems

As a “channel opener” for living organisms, DMSO can develop its effect anywhere in the body and, as a carrier, ensure that medicinal agents reach their destination quickly. Because it effortlessly penetrates the membrane of biological cell tissue, it reaches less accessible body regions such as adipose tissue or joint capsules for other substances, passes even the blood-brain barrier and can trigger and accelerate the removal of toxins, deposits and other metabolic products. Thanks to these properties, regular intake of DMSO can even make it easier to lose weight.


DMSO – Application on the skin

Health-promoting or curative agents whose effects dimethylis sulfoxidum can optimize include salts such as magnesium chloride, amino acids, vitamins (both the water-soluble B vitamins also the fat-soluble A, D, E and K), lactic acid, iodine, hydrogen peroxide, sulfur, selenium, colloidal silver, borax, alpha lipoic acid and many more. Dimethyl sulfoxide is also used in manual, mechanical and wave-based procedures such as acupuncture, osteopathy, magnetic field, shock wave and ultrasound therapy or the bioresonance method: A rubbing of the relevant parts of the body before the actual treatment begins can optimize their efficiency.


How does the skin react to rubs with DMSO?

When methyl sulfoxide is used in aqueous solutions, a spontaneous, very rapid heat development can be felt. This is due to its ability to break water molecules into their atomic components acid and hydrogen. The destruction of this bond releases energy that heats the liquid. It is precisely this “break-up” of molecules that is responsible for the numerous health-promoting interactions of this natural remedy with the transport routes and cells of the body. This starts with the application to the skin. The reduction of the surface tension while increasing the permeability can lead to slight tingling and tender redness, but also produce severe itching to the feeling of being too close to a nettle. If this reaction is perceived as unpleasant, rinsing the solution with water helps. For further treatment, the concentration of the mixed remedy is diluted by further addition of purified water.


Characteristic smell after oral use

For holistic health promotion, the product can also be drunk heavily diluted with water. Inside the body, methylsulfinylmethane almost completely converts into the also organic sulphide compound MSM. This splitting is therapeutically desired. For example, scientific studies show the healing influence of MSM in arthritis, rheumatism, bladder or mucous sac inflammation and fibromyalgia postulated by naturopath Robert Franz.

The strange smell of garlic, wild garlic or oysters, which many users describe, is the source of the residual substance in the organism. Just like garlic aromas, the evaporations of organic sulfur compounds are excreted by the breath and, to a lesser extent, by the skin. Brushing teeth and showering help to neutralize the smell. But as with garlic, it can take 36 to 48 hours to smell anything.


Dangerous interaction: Plastic and DMSO

The use of methyl sulfoxide must in any case be done with care: whether in pure form or diluted – it must not come into contact with plastic. This applies to containers as well as to cosmetics and other preparations containing plastic in nanoparticles. Thanks to the properties described, it can release potentially harmful substances such as heavy metals, plasticizers, stabilizers and other industrial additives from plastic surfaces and discharge them into the body cells. An exception is HDPE, a plastic that is the only one approved for storage and transport. Pipettes and spray heads made of this material are occasionally supplied as dosing aids.

Which DMSO is the best?

The first and most important indication is the certification of pharmaceutical quality according to the European Pharmacopoeia. One of the most proven products with this seal of approval is DMSO from WoldoHealth (bestseller on Amazon). The most important features:

  • 99.9 percent pharmaceutical purity, free of additives
  • bipolar (fat- and water-soluble) organic solvent
  • is made from tree wood
  • dilutable with water, ointment, gel, cream, spray, etc.
  • Means of transport for accelerating and reinforcing the active ingredients in pain ointments and essential oils
  • Original product, light-protected in brown glass bottle with pipette
  • 100 millilitres capacity
  • excellent price-performance ratio: 8.99 euros per 100 milliliters


In addition to the 99.9 percent pure form, DMSO eye drops, face creams, gels for application to joints, gums, nails and so on are also offered. If you want to buy DMSO, you can find it in the online shops of WoldoHealth, at Robert Franz, etc.

Amazon allows you to compare a wide range of manufacturers, retailers and high-quality products. With a bit of luck, there is also a pharmacy in the neighborhood in stock (usually at a higher price). Drugstores in Germany currently do not carry the substance in pure form or in drug combinations. Even in health food stores or organic shops, it is very rarely part of the range. The sulfur compound is also over-the-counter in high concentrations. The labelling according to the European Pharmacopoeia in a pharmaceutical purity of 99.9 percent ensures the high quality of the product. Buying certified DMSO carries no risk. Differences between the different brands can be seen mainly in containers, medium of dosing, available filling quantity(s) and pricing. The latter varies, of course, for example through discount promotions. Therefore, it is not included in the following table.


Dimethyl sulfoxide pharmaceutical 99.9 purity – popular brands in comparison

Provider/Manufacturer WoldoHealth Robert Franz Reaxon Filzada Naturtotal Carino Healthcare
Container Brown glass bottle very dark Miron glass (pharmacist bottle) Brown glass bottle Brown glass bottle Pharmacist bottle made of brown glass Brown glass bottle
Dosing aid Pipette made of HDPE, a suitable plastic no dosing aid Drip closure made of DMSO-resistant material Dosage by drip closure Glass pipette
Filling quantity(s) 100 ml 100 ml 100 ml 250 ml 1,000 ml 100 ml

What complaints does DMSO help against?

Acne, inflammatory pimples, herpes and warts

Acne or other pimples usually bloom on the face. A 25 percent dimethyl sulfoxide solution (1 part active ingredient plus 3 parts water is generally recommended for DMSO for use on the face) provides a quick remedy. The agent has an anti-inflammatory effect, which means that although it does not fight the cause of the inflammation, it can attenuate its intensity as well as side effects such as itching or pain.

Against painful lip herpes – preferably in the early stage, already at the first signs – can also be successfully tackled with a solution in the same active ingredient concentration, i.e. diluted with 3 times the amount of water. Because it penetrates the skin barrier without any problems, it enters directly into the source of inflammation. Thus, dimethyl sulfoxide can develop its antiviral and analgesic effect. Tip: If you want to know more about the antiviral mode of action of the drug especially against herpes of the lips and genitalorgans, the handbook Nature’s Healer by Dr. Morton Walker (now also in German translation of the American original edition) should be recommended.

Its antiviral properties make methylsulfinylmethane a highly effective remedy against warts and other skin growths caused by viruses. Exceptionally, a much higher concentration is recommended here, namely a solution of 7 parts of the active ingredient in 3 parts water. This 70 percent solution should be applied directly to the wart with a cotton swab up to three times a day until it has dried up and or falls off.

Arthritis and osteoarthritis

The treatment of arthritis is a prime example of the anti-inflammatory effects of DMSO. Its effect in rheumatoid arthritis, an autoimmune reaction of the body that destroys the cartilage tissue around the joints, has also been a concern in conventional medicine since the late 1980s. The disease itself cannot fight it, but it does be the hardening, swelling and painful limitations of the musculoskeletal system that accompany it. The remedy of choice is a DMSO ointment: 7 parts of the active substance are diluted with 3 parts water, supplemented by 10 percent glycerine (10:1) as well as some diclofenac gel and applied to the affected parts of the body.

Sulfinyldimethane can also have a soothing effect on chronic osteoarthritis (irreversible joint damage, for example due to injury, over- or incorrect loading). The active substance is used in the same composition as with arthritis or as a simple 25 percent solution.

Use in sports medicine

Bruising, wounds, dents, bruises, bruises, aching muscles and joints are a productive field for numerous human medicine disciplines, physiotherapy and alternative treatment methods. A bruising, also called “blue spot” or hematoma, is caused by one or more injured blood vessels that release blood into the surrounding tissue, body cavities or joints. Repeated use (up to 3 times daily) can accelerate metabolism by dilating the vessels and improve blood circulation, thus limiting and reducing swelling. If the active substance is applied in a timely manner after an injury, it can even prevent the affected area from swellingat all. [1]

The same applies to muscle damage: dimethyl sulfoxide helps with healing and regeneration and promotes the growth of muscles. Light sports injuries that can be treated with pain ointments heal faster when DMSO is used as a transmitter in ointment, cream or gel. However, it is worth first testing the analgesic effect of a simple dimethyl sulfoxide mixture with water. Even inflammation of the tendons (e.g. the tennis arm) can be effectively treated with it. Since these are diseases of the extremities, the concentration of the drug may be slightly stronger until the end of the

In the case of tendinitis, for example in the tennis arm, or tendinitis on the wrist, it has an anti-inflammatory and analgesic effect. Since the arms or legs are usually affected, a high-percentage sulfinyldimethane solution can be applied several times until the discomfort settles down.

Diseases of the digestive tract

Mostly stress-related stomach and intestinal diseases have been increasing for years. In the case of inflammatory diseases such as Crohn’s disease, ulcerative colitis or stomach ulcers, the digestive process is permanently out of balance. The oral administration of dimethyl sulfoxide can, as experience shows, have a calming and anti-inflammatory influence and protect the gastric mucosa. [2] It also enhances and accelerates the effectiveness of drugs. As with all internal applications, it is also recommended to take a more diluted solution, i.e. 1 part active ingredient on 5 to 7 parts of water, in case of discomfort of the digestive system. Good to know: If you regularly take it as a dietary supplement, your breath exudes a smell that cannot be neutralized at first. Pleasing side effect: A continuous oral administration of DMSO can help with weight loss by releasing energies for sports activities and thus also indirectly contributing to stress relief.

Itching, Stitches, Bites

Sounds lapidary, but it’s true: when the skin itches, applying a dimethyl sulfoxide solution almost always helps. In the right dosage, it gently handles the skin gently and supports the natural healing process.

In case of allergic reactions to an insect bite or an unpleasant contact dermatitis, it relieves pain and itching, counteracts swelling and prevents inflammation or fights its symptoms. [3] The concentration of the solution in water again depends on the body part (see below).

Blood-hungry ticks are on the rise in Europe and can transmit dangerous ones. Early treatment of the bite site with DSMO helps in the prevention of infection, as experience with the agent shows. It must be applied directly to the often inconspicuous wound in a high concentration (70 percent) over several days. If the redness increases, it migrates or if flu-like symptoms such as fatigue, fever and headache arise, the doctor must be consulted.

Headaches and painful illnesses

The medicinal substance can successfully replace or at least supplement aspirin and other painkillers. Especially tension headaches usually disappear after a single application of a 25 percent solution, in case of cold-related sore throat can bring multiple application relief. [4]

Taken orally, DMSO strengthens the immune system and helps the body regain strength. If the gums are painful, once or more tups with diluted solution helps. In chronic and / or non-specific, repeated or persistent pain or fibromyalgia, it has also proven to be an analgesic, at least -reducing agent. Dr. Fischer’s handbook is largely devoted to the wide range of applications of dimethyl sulfoxide in pain control.

Wound healing and supply of fire bubbles

Used for the treatment of bruised skin areas, for shallower cuts and scratches as well as for slight burns up to fire bubbles, sulfinyldimethane contributes to a rapid wound healing. It helps with the rapid regeneration of damaged skin layers and can prevent scarring. First, the wound should be carefully cleaned, for example by gently rinsing with warm to lukewarm water. Connect the edges are dribbled and a diluted solution (corresponding to the body region) is sprayed into water. Applying, tumping or brushing would further irritate the damaged areas of the skin and also hurt. [5]

So much for the tips for self-treatment. In addition to universal usability as a home remedy in a wide variety of malaises, the hydrophilic and lipophilic substance is also widely used in controlled therapeutic and school medicine contexts, for example in the cure of urinary tract infections, non-bacterial bladder and prostate inflammation, shingles and cancers (see the manual “DMSO – the application in medicine” for clinical examination of new developments based on this drug. , Berlin).

DMSO is also used in ophthalmology as an eye ointment or in drop form, for example in degeneration of the macula. Last but not least, it also works in cosmetic-aesthetic contexts: Naturopath Robert Franz swears by the effectiveness of the derivative MSM with incipier hair loss and offers a corresponding preparation. The regenerating effects on cell stability in transplant organs (see above) allow the assumption that dimethylis sulfoxidum, similar to Botox – and far more harmless – can counteract the formation of wrinkles, as it tightens and stabilizes the connective tissue, makes it more receptive to hyaluron and optimizes overall skin image.

Side effects

The use of this natural remedy is normally harmless. Are there any side effects? The literature on use in human medicine describes very few side effects of DMSO, usually only minor. Experiences such as mild nausea or redness of the skin are occasionally reported, but most of the time these side effects disappear quickly.

In special life situations and in a number of pre-existing conditions, DSMO should only be used after consultation with a doctor. This applies, for example, to children who have reached the age of 6, as well as to pregnant women and mothers in breastfeeding. It has already been mentioned that DSMO should be withheld if the first external or internal application provokes a significant hypersensitivity. As an undesirable skin reaction when applying the substance, dandruff can occur, among other things. [6]

Dimethylis sulfoxidum is contraindicated in neurodermatitis and psoriasis. Because DMSO can strongly influence the metabolic process in the body, it is strongly advised not to use it in diabetes as well as in diseases of the liver or kidney.

How is DMSO taken or how to dose it?

Preparation – Avoid or neutralize plastics

Glass, porcelain or metal are always the materials of choice for measuring, adding, diluting, storing and in use. However, utensils such as spray heads, disposable syringes or pipettes are usually at least partially made of plastic. They must be neutralized before therapeutic use by thorough, repeated rinsing with a few milliliters of 99.9 percent methyl sulfoxide.

Containers for DMSO ointment, injection solutions, drinking solutions with DMSO or eye drops do not need to be pre-treated. With, for example, at least 4 parts of water mixed, this active ingredient behaves neutrally against plastics. It can be safely filled into the sterilized disposable articles, mixed with the desired additives and / or stored. For hygienic reasons, the manual recommends using distilled or boiled or sterilized water to start the solution, but experience shows that it also does simple tap water.


Self-treatment with DMSO

For application on your own skin, it is useful to first test the concentration on a small spot in order to adjust it if necessary. Most often, the skin of the limbs and back tolerates a higher dosage than the torso areas of the abdomen and chest. Also careful should be with the active ingredient concentration, who easily gets sunburn, so usually people with light skin and / or similar eyes.

The following mixing ratios from active substance to water represent indicative values, which must be modified according to the individual constitution:

  • Face and head: 1 to 3 (25 percent solution)
  • Abdomen, chest and rest of the upper body: 1 to 1 (50 percent solution)
  • Extremities and warts: 7 to 3 (maximum 70 percent solution)
  • Gums: 3 to 1 (75 percent solution) or pure (sparingly pluck!)
  • DMSO in eye drops: 1 to 100 (1 percent solution)


What should be considered when applying the solution?

  • Place mixed medium and other necessary utensils on a clean backing: if necessary, pipette, brush, cotton swabs, cloths
  • Completely expose the body region in question – no garments should come into contact with the solution
  • Wash hands thoroughly with warm water and soap.
  • The same applies to the body part, it must be completely free of make-up, cosmetics, creams, etc.
  • Find a comfortable sitting or lying position that allows to treat the corresponding skin area completely and from all sides.
  • Methyl sulfoxide can cause unsightly stains on wood or fabric, therefore working on a base.
  • Sprinkle the area with the pipette or wet it with the spray bottle. Don’t rub it! Thanks to the properties described above, the remedy finds its own ways in and through the skin.
  • Until the active substance is absorbed by the body, the solution must act for about half an hour. Then wash off with water.


Oral use

As a guideline for ingestion, the manual recommends 0.1 grams of DMSO per kilo of body weight in adults. This must not be done in pure form – even a 10 percent solution can cause nausea and indigestion. Similar to the dosage of DMSO for eye drops, the substance to be drunk in a solution is strongly diluted to 1 to a maximum of 2 percent.

One of the side effects of the sulfur compounds working in the organism is also a more or less strong odour, which is not possible to neutralize other than by waiting. A consolation may be that DMSO facilitates weight loss if it is taken regularly as a dietary supplement.

Conclusion: Why is DMSO so healthy?

Proven as a home remedy, widely used in school and alternative medicine, in physiotherapy and other therapeutic procedures: The broad spectrum of effects of dimethyl sulfoxide is far from being fully explored. In addition to the countless beneficial effects as a pure active ingredient-water combination for pain, inflammation, injuries, immunodeficiency, etc., DMSO also serves as a means of transport and accelerator of other healing substances. It is usually offered in liquid pure form, as well as dosage forms such as DMSO eye drops as well as DMSO ointment, gel and spray. His successes in tumor treatment as well as in autoimmune diseases such as amyloidosis or scleroderma are the subject of numerous studies. DMSO can help you lose weight. It’s worth buying a vial of 99.9 percent certified DMSO solution to be prepared for the smaller and larger imperfections of everyday life such as headaches, inflammation of the gums, bruises or painful insect bites.

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